论文部分内容阅读
在洋地黄过量和中毒的处理中,最令人鼓舞的进展是使用解毒剂,即特异性的抗地高辛抗体。这种抗体由羊体内产生,通过特异性的免疫吸附法分离出来。由于这种完整的免疫球蛋白的分子量很大,所以在体内的分布受到限制。即使与地高辛结合,也不能被肾脏排泄。但可用木瓜蛋白酶将这种IgG分子水解成3个片段;一个可结晶的片段(Fc段)为无作用部份;二个Fab段,每一个的分子量约为50,000,并具有能与抗原特异性结合的部位。
The most encouraging development in the handling of digitalis excess and poisoning is the use of antidotes, the specific anti-digoxin antibodies. This antibody is produced in sheep and isolated by specific immunosorbent assay. Due to the large molecular weight of this complete immunoglobulin, the distribution in the body is limited. Even with digoxin, can not be excreted by the kidneys. However, this IgG molecule can be hydrolyzed by papain into 3 fragments; one crystallizable fragment (Fc fragment) is an inactive moiety; and two Fab fragments, each having a molecular weight of about 50,000, and capable of hybridizing to antigen-specific The site of binding.