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目的观察米非司酮治疗围绝经期功能性子宫出血的临床效果。方法将 4 4例确诊为围绝经期功能性子宫出血患者 ,口服米非司酮 10mg,每日 1次 ,连服 3个月 ,观察子宫大小、内膜厚度及月经恢复情况。结果子宫内膜变薄 ,用药前为 (5 .8± 0 .2 )mm ,用药后为 (2 .7± 0 .3)mm ,前后比较有显著性差异 (P <0 .0 5 ) ;子宫大小用药前后无明显差异 (P >0 .0 5 )。所有患者用药期间均闭经 ,其中有 9例直接进入绝经 ,其余停药后 2 5 6 8天 ,平均 4 0 .4天恢复月经 ,15例月经稀发、量少。结论米非司酮可抑制子宫内膜生长 ,治疗围绝经期功能性子宫出血效果可靠。
Objective To observe the clinical effect of mifepristone in treating peri-menopausal dysfunctional uterine bleeding. Methods Forty four patients with functional uterine bleeding who were diagnosed as perimenopausal period were given oral mifepristone 10 mg once daily for 3 months. The uterine size, endometrial thickness and menstrual recovery were observed. Results The endometrial thinning was (5.2 ± 0.2) mm before treatment and (2.7 ± 0.3) mm after treatment, with significant difference before and after treatment (P <0.05). Uterine size before and after treatment no significant difference (P> 0.05). All patients were amenorrhea during the medication, of which 9 cases directly into the menopause, the remaining 256 days after withdrawal, an average of 40 days to resume menstruation, 15 cases of menstruation thinning, less. Conclusion Mifepristone can inhibit the growth of endometrium, and it is reliable in treating peri-menopausal dysfunctional uterine bleeding.