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目的探讨绝经后女性2型糖尿病患者骨密度与冠心病的相关性。方法对176例符合1999年世界卫生组织(WHO)糖尿病诊断标准的绝经后女性2型糖尿病住院患者,应用骨密度仪测定骨密度和T值,根据有无冠心病分为2组,比较骨密度和T值。应用多因素非条件Logistic回归分析的相关性。结果绝经后女性2型糖尿病合并冠心病组的骨密度、T值显著低于不伴有冠心病组(P<0.01~0.05),调整了年龄、血压、血脂、体重指数、糖尿病病程、绝经时间后,经多因素非条件Logistic回归分析显示骨质疏松与冠心病仍存在显著的相关性(Or=4.465,95%CI:1.650~11.230)。结论绝经后女性2型糖尿病患者骨密度降低可能与冠心病的发生、发展有关。
Objective To investigate the correlation between bone mineral density and coronary heart disease in postmenopausal women with type 2 diabetes mellitus. Methods A total of 176 hospitalized patients with type 2 diabetes of postmenopausal women diagnosed according to World Health Organization (WHO) Diabetes Mellitus (WHO) in 1999 were enrolled in this study. BMD and T values were measured by BMD. According to the presence or absence of coronary heart disease, And T value. Application of multivariate non-conditional Logistic regression analysis of the correlation. Results The bone mineral density and T value of type 2 diabetes mellitus with coronary heart disease were significantly lower in postmenopausal women than in those without coronary heart disease (P <0.01 ~ 0.05), and adjusted for age, blood pressure, blood lipid, body mass index, duration of diabetes mellitus, After multivariate non-conditional Logistic regression analysis, there was still a significant correlation between osteoporosis and coronary heart disease (Or = 4.465, 95% CI: 1.650-11.230). Conclusion The decrease of bone mineral density in postmenopausal women with type 2 diabetes mellitus may be related to the occurrence and development of coronary heart disease.