前列腺素F_(2α)的抗着床作用约为F_(1α)的10倍,而前者与后者仅在α链上有一个顺式双键之差,因此,作者认为前列腺素α链上双链的变化可能是抗着床作用的重要因素,因而合成了60多个α链上含有各种不同双键的前列腺素类似物,测定了它们的抗着床效力,并与已知抗着床作用较高的前列腺素F_(2α)作了比较。结 The anticoagulant effect of prostaglandin F_ (2α) is about 10 times that of F_ (1α), whereas the former and latter only have a difference of cis-double bonds in α-chain. Therefore, Changes in the chain may be an important factor in anti-implantation, thus synthesizing more than 60 prostaglandin analogues containing a variety of different double bonds in the α-chain, their anti-implantation efficacy was measured and compared with known anti-implantation The higher prostaglandin F_ (2α) was compared. Knot