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目的总结阴沟杆菌下呼吸道感染的临床特点及该菌对常用抗生素的敏感性。方法（１）分析５８例阴沟杆菌所致肺部感染的临床资料，包括年龄、基础疾病、发病诱因、症状体征、Ｘ线表现、治疗转归等；（２）以Ｋ－Ｂ法（纸片法）或Ｅｔｅｓｔ法（ＭＩＣ纸片法）测定该菌的体外药物敏感性。结果（１）男４６例，女１２例，年龄５６±１９岁，８８％的患者有基础疾病，其中以慢性阻塞性肺疾病（ＣＯＰＤ）最常见，４１％的病例为混合感染，混合菌主要为绿脓杆菌、肺炎克雷白杆菌和真菌。症状为发热（７２％）和咳嗽、咳痰（８７％），胸部Ｘ线表现为分布于两下肺野的支气管肺炎改变，病死率为９％。（２）药敏试验提示该菌呈现多重耐药，亚胺培南、丁胺卡那、妥布霉素、环丙沙星、头孢哌酮为较敏感抗生素。结论阴沟杆菌肺部感染患者多有基础疾病，临床表现不典型，以支气管肺炎改变为主，诊断依靠病原学并结合临床及Ｘ线检查，治疗应根据药敏并联合应用抗生素。
Objective To summarize the clinical characteristics of lower respiratory tract infection of cloacae and the susceptibility of the bacteria to commonly used antibiotics. Methods (1) The clinical data of 58 cases of lung infection caused by Corynebacterium embodilum were analyzed, including age, basic disease, inducement, symptoms and signs, X-ray findings and treatment outcome. (2) Method) or Etest method (MIC paper method) to determine the in vitro drug sensitivity of the bacteria. Results (1) There were 46 males and 12 females, aged 56 ± 19 years. 88% of the patients had underlying diseases. Chronic obstructive pulmonary disease (COPD) was the most common and 41% of the cases were mixed infections. The main mixed bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and fungi. Symptoms of fever (72%) and cough, sputum (87%), chest X-ray showed distribution of bronchial pneumonia in the lower lung field changes, the mortality rate was 9%. (2) Susceptibility test showed that the bacteria showed multi-drug resistance. Imipenem, amikacin, tobramycin, ciprofloxacin and cefoperazone were more sensitive antibiotics. Conclusions Patients with lung flu bacilli have more underlying diseases and their clinical manifestations are not typical. The main changes are bronchopneumonia. Diagnosis depends on etiology and combined with clinical and X-ray examination. Antibiotics should be combined according to drug sensitivity and combination therapy.