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争光霉素即博莱霉素(Bleomycin)为一组具有糖肽结构的抗癌抗菌素。争光霉素沪Ⅰ号相当于日本博莱霉素Bleocin。国内外曾对这种争光霉素进行过各种放射性同位素标记,并进行过实验与临床研究,发现~(57)Co-争光霉素对肿瘤有一定的亲和性,已用于临床肿瘤的“阳性”定位。但由于~(57)Co的物理半衰期过长(270天),因而较难推广。其他放射性同位素如~(111)In-、~(99m)Tc-、~(67)Ga、~(67)Cu等虽也有报道,然而由于标记物的体内稳定性差而影响了其对肿瘤的定位效果。放射性碘为临床常用的示踪核素,故亦
Blenomycin (Bleomycin) is a group of anticancer antibiotics with a glycopeptide structure. Zeocin Shanghai No. I is equivalent to Japan’s Bleocin Bleomycin. A variety of radioisotope labels have been used at home and abroad for this kind of bleomycin, and experimental and clinical studies have been conducted. It has been found that ~(57)Co-conquestion has a certain affinity for tumors and has been used in clinical tumors. “Positive” positioning. However, because the physical half-life of ~(57)Co is too long (270 days), it is difficult to generalize. Other radioisotopes such as ~(111)In-, ~(99m)Tc-, ~(67)Ga, ~(67)Cu, etc. have been reported, however, due to the poor stability of the markers in vivo, their localization to the tumor has been affected. effect. Radioactive iodine is a commonly used tracer radionuclide in clinical practice.