Werner综合征,又称成人型早期老化综合征,此病作为人老化的模型是很理想的,因此,近起受到人们的重视。1966年,Epstein等,综合过去报导的约150例,指出此综合征与人老化有明显的类似性。此病见于青年人,表现为全身性硬皮症和白内障并发,属于常染色体隐性遗传性疾病。常出现动脉硬化、白发、老人样面容、声音嘶哑、糖尿、不孕、致癌倾向等。平均寿命47岁,多因心肌梗塞、脑溢血、癌症等而死亡。检查无特异性发现,但是,Hayflick等报告,皮肤成纤维细胞的寿命极其短暂,细胞培养发现是老化的良好模型。另外,尿内粘多 Werner syndrome, also known as adult-type early-stage syndrome, the disease as a model of aging is ideal, therefore, from the near by people’s attention. In 1966, Epstein et al., Combined with about 150 cases reported in the past, pointed out that this syndrome has obvious similarities with aging. The disease seen in young people, manifested as systemic sclerosis and cataract complicated by autosomal recessive genetic disease. Often appear atherosclerosis, white hair, the elderly face, hoarse voice, diabetes, infertility, carcinogenic tendencies and so on. The average life expectancy is 47 years old, mostly due to myocardial infarction, stroke, cancer and death. No specific findings were examined, but Hayflick et al. Reported that the lifespan of skin fibroblasts was extremely transient and cell culture was found to be a good model of aging. In addition, the urine sticky