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目的:优选通脑精胶囊的提取工艺。方法:利用正交试验法,考察乙醇用量(A)、回流次数(B)、回流时间(C)3个因素对提取工艺的影响,每个因素设计3个水平,大黄素、干浸膏为考察指标成分;用薄层扫描法测定大黄素含量,烘干法测定干浸膏得率。结果:因素B、C对指标成分含量有显著性意义,最佳提取工艺为A2B3C3即乙醇用量为药材质量的10倍量、8倍量、8倍量,煎煮3次,提取时间分别为2h、1.5h、1.0h。结论:正交试验法筛选通脑精胶囊生产工艺简便、快速、准确。
Objective: To optimize Tongnong Capsules extraction process. Methods: The orthogonal test was used to study the effect of three factors (A, B, and C) on the extraction process. Three factors were designed for each factor. Emodin and dry extract were The index components were investigated. The content of emodin was determined by TLC and the dry extract was determined by drying method. Results: The factors B and C had significant significance on the content of the indicator components. The best extraction process was A2B3C3, which was 10 times the amount of ethanol, 8 times the amount of 8 times the amount of ethanol, boiling 3 times, the extraction time were 2h , 1.5h, 1.0h. Conclusion: Orthogonal test screening Tongnong Capsules production process is simple, fast and accurate.