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系于羊膜腔穿刺术产前诊断神经管缺陷(NTD)的必要性,最近有些文章一直在争论这个问题。1986年首次报道了脊柱裂超声检查的颅内征象。加州从1986年4月开始,用母血清AFP测定筛选NTD就成为强制性的。大量孕妇进行母血清AFP筛选检查,对超声检查在查出NTD方面的作用进行新的观察。现报告1988年1月～1990年6月通过加州母血清AFP筛选方案查明的161例脊柱裂病人的超声检查情况。
Necessity of prenatal diagnosis of neural tube defects (NTDs) by amniocentesis, and some articles have been debating this issue recently. For the first time in 1986, the intracranial signs of spina bifida ultrasound were reported. California Since April 1986, screenings for NTD using maternal serum AFP have become mandatory. A large number of pregnant women were tested for AFP screening of maternal serum and new observations were made on the role of ultrasonography in the detection of NTD. A report on the ultrasound examination of 161 patients with spina bifida identified through the California AFP screening program from January 1988 to June 1990 is now reported.