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目的研究元宝枫油的食用安全性。方法采用小鼠急性经口毒性试验、遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验)及亚慢性毒性试验(大鼠90天喂养)对元宝枫油的食用安全性进行评价。结果元宝枫油对雌、雄性小鼠经口LD50均大于54 000 mg/kg BW,属无毒级;3项遗传毒性试验结果均为阴性;以10 800、5 400、2 700 mg/kg BW 3个剂量的样品液连续给大鼠灌胃90 d,实验期间动物生长发育良好,各项检测指标均未见异常。结论元宝枫油在本实验条件下为无毒物,未显示有急性、亚慢性毒性及遗传毒性。
Objective To study the edible safety of ingrown maple oil. Methods Acute oral toxicity test in mice, genotoxicity test (Ames test, mouse bone marrow micronucleus test and mouse sperm abnormality test) and subchronic toxicity test (90 days rat feeding) Sexual evaluation. Results The results showed that the LD50 of the aroma oil in female and male mice was more than 54 000 mg / kg BW, which was non-toxic. All three genotoxicity tests were negative. Three doses of the sample solution were continuously fed to rats for 90 days. During the experimental period, the animals grew well and no abnormality was detected in all the indexes. Conclusion Acer aspirin is non-toxic under the experimental conditions, and does not show acute, subchronic and genotoxic effects.