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肾细胞是常见的泌尿系肿瘤之一,对于转移性的肾细胞癌靶向药物已经成为标准治疗方案,但是靶向药物的完全缓解率非常低,大多数的患者在最初治疗有效后很快发生肿瘤进展。因此肾细胞癌的免疫治疗随着肿瘤免疫学机制研究的发展再次成为研究的热点。本文总结了已经完成临床试验的肾细胞癌免疫治疗方法,根据免疫治疗的原理主要从T细胞调节剂、细胞过继免疫治疗、疫苗以及免疫治疗与其他治疗联合应用等方面介绍了肾细胞癌免疫治疗的临床研究进展,分析了免疫治疗在肾细胞癌治疗领域基本状况、需要解决的问题以及未来的发展趋势及应用前景。
Renal cells are one of the most common urological tumors and have become the standard treatment for metastatic renal cell carcinoma, but the rate of complete remission of targeted drugs is very low, with most patients occurring very soon after the initial treatment is effective Tumor progression. Therefore, the immunotherapy of renal cell carcinoma with the development of tumor immunology mechanism research once again become the focus of research. This article summarizes the clinical trials of renal cell carcinoma immunotherapy methods, according to the principle of immunotherapy mainly from T cell regulators, adoptive immunotherapy of cells, vaccines and immunotherapy combined with other treatment applications introduced renal cell carcinoma immunotherapy Clinical research progress, analyzed the immunological treatment in the treatment of renal cell carcinoma in the basic situation, the problems to be solved and the future development trends and application prospects.