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目的:比较埃索美拉唑联合奥美拉唑治疗反流性食管炎的效果。方法:60例随机分为两组,治疗组30例口服埃索美拉唑40mg qd*4w,之后20mg qd*4w;对照组30例口服奥美拉唑40mg qd*4w,之后20mg qd*4w,均合用莫沙必利5mg tid。治疗4周、8周分别作症状评价和胃镜评价。结果:两组症状均有明显改善,治疗组疗效高于对照组,有显著差异(p<0.05);治疗8周后胃镜下疗效观察,治疗组疗效明显高于对照组,有显著差异(p<0.05)。结论:埃索美拉唑治疗反流性食管炎有效、安全,疗效比奥美拉唑更好。
Objective: To compare the effect of esomeprazole and omeprazole in the treatment of reflux esophagitis. Methods: Sixty patients were randomly divided into two groups. The treatment group was given 30 mg esomeprazole 40 mg qd * 4 w and then 20 mg qd * 4 w. In the control group, 30 patients were omeprazole 40 mg qd * 4 w, then 20 mg qd * 4 w , Are combined with mosapride 5mg tid. Treatment for 4 weeks, 8 weeks for symptom evaluation and endoscopy evaluation. Results: The symptoms of both groups were significantly improved, and the therapeutic effect was higher in the treatment group than in the control group (p <0.05). After 8 weeks of treatment, the efficacy of endoscopy was significantly higher in the treatment group than in the control group (p <0.05). Conclusion: Esomeprazole is effective, safe and effective than omeprazole in the treatment of reflux esophagitis.