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目的观察慢性丙型肝炎患者在干扰素抗病毒治疗时 ,对白细胞介素含量的影响。方法对 2 8例以IFN -a作抗病毒治疗的丙肝患者 ,采用ELISA法进行血清IL -2、IL -4及IL -1 2检测。结果三者在治疗前的含量分别为 1 4 .0 6± 1 2 .63pg/m1、57.89± 61 .78pg/m1和 2 30 .55± 4 2 0 .56pg/m1。治疗结束 (第 2 4周 )时IL -2测值不变 ,IL -4测值下降至 30 .4 1± 4 0 .73pg/m1 ,IL -1 2上升至 57.89± 61 .78pg/m1。随访时 (第 4 8周 )三者恢复至抗病毒治疗前水平。 结论采用外源性IFN -a进行抗病毒治疗时 ,慢性丙型肝炎患者血清IL -4及IL -1 2等与T淋巴细胞分化发育相关的细胞因子的含量出现一过性改变 ,这种变化是外源性IFN调节体内T淋巴细胞分化发育的证据之一。
Objective To observe the effects of interferon antiviral therapy on interleukin in chronic hepatitis C patients. Methods Serum IL-2, IL-4 and IL-12 levels were measured by ELISA in 28 hepatitis C patients treated with IFN-α as an antiviral agent. Results The content of the three before treatment were 14.06 ± 1.263 pg / ml, 57.89 ± 61.78 pg / ml and 230.555 ± 42.056 pg / ml, respectively. At the end of treatment (week 24) IL-2 measured unchanged, IL-4 decreased to 30.41 ± 40.73pg / ml and IL-2 increased to 57.89 ± 61.78pg / ml. At follow-up (week 48), the three returned to pre-antiviral levels. Conclusions In the antiviral treatment with exogenous IFN-α, the levels of IL-4 and IL-1 in serum of patients with chronic hepatitis C have a transient change in the content of cytokines related to the differentiation and development of T lymphocytes. It is one of the evidences that exogenous IFN regulates the differentiation and development of T lymphocytes in vivo.