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目的:评价替硝唑片与克林霉素磷酸酯阴道凝胶剂对细菌性阴道炎患者的临床疗效及其安全性。方法:选取2014年1月—2016年1月间收治的细菌性阴道炎患者110例,将其随机分为对照组和观察组,每组55例;对照组患者给予替硝唑片口服治疗,观察组患者在对照组基础上加用克林霉素磷酸酯阴道凝胶剂治疗;比较两组患者治疗后的总有效率、用药期间不良反应的发生率和半年后的复发率。结果:两组患者用药期间不良反应的发生率经组间比较其差异无统计学意义(P>0.05);观察组患者治疗后的总有效率高于对照组(P<0.05),致病菌的清除率高于对照组(P<0.05),治疗半年后的复发率低于对照组患者(P<0.05)。结论:采用替硝唑与克林霉素磷酸酯阴道凝胶联用治疗细菌性阴道炎患者的临床疗效优于单用替硝唑片的治疗,且复发率低,致病菌的清除率高。
Objective: To evaluate the clinical efficacy and safety of tinidazole and clindamycin phosphate vaginal gel in patients with bacterial vaginosis. Methods: One hundred and ten patients with bacterial vaginosis admitted from January 2014 to January 2016 were selected and randomly divided into control group and observation group, with 55 cases in each group. Patients in the control group were treated with tinidazole tablets orally, Patients in the observation group were treated with clindamycin phosphate vaginal gel on the basis of the control group. The total effective rate, the incidence of adverse reactions during the treatment and the recurrence rate after six months were compared between the two groups. Results: There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The total effective rate in the observation group was higher than that in the control group (P <0.05) (P <0.05). The recurrence rate after six months of treatment was lower than that of the control group (P <0.05). Conclusion: The clinical efficacy of tinidazole combined with clindamycin phosphate vaginal gel in the treatment of bacterial vaginosis is better than that of tinidazole alone, and the recurrence rate is low and the clearance rate of pathogens is high .