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血浆皮质醇水平的变化反映肾上腺皮质的分泌和组织器官对皮质醇的降解转化作用。生理状态下下丘脑-垂体-肾上腺轴控制皮质醇的合成和分泌。血浆皮质醇浓度升高抑制垂体促皮质素(ACTH)的释放。起激素自身负反馈控制作用。生理状态下下丘脑-垂体-肾上腺轴调节控制作用使昼夜间的血浆皮质醇水平呈节律性变化。肝脏是糖类皮质素作用的主要靶器官和降解转化场所。我们曾报告了各种肝病时血浆皮质醇的变化,本文又进一步观察了肝硬变病人血浆皮质醇昼
Changes in plasma cortisol levels reflect the secretion of adrenal cortex and tissue and organ cortisol degradation and conversion. The hypothalamus-pituitary-adrenal axis under physiological conditions controls the synthesis and secretion of cortisol. Increased plasma cortisol suppresses the release of pituitary cortisol (ACTH). Hormonal self-negative feedback control. Physiological state hypothalamus - pituitary - adrenal axis regulation and control of day and night plasma cortisol levels were rhythmic changes. Liver is the main target organ of the role of cortisol and degradation of conversion sites. We have reported changes in plasma cortisol in a variety of liver diseases, this paper further observation of patients with cirrhosis of plasma cortisol day