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苯二氮(艹卓)类在1960年引入后的数年内,卓有成效地取代巴比妥类而作为治疗焦虑和失眠的首选药物,此外,亦可作为抗惊厥药和肌肉松弛药。 1.表明药物依赖性的证据众所周知,任何药物包括安慰剂均能产生心理依赖性,因此,仅仅要求继续用药还不足以说明存在药理依赖性。但是如果因药物产生欣快感或能预防不适而患者主动谋求药物,则表明此药存在具药理作用的心理依赖性。迅速产生耐受性,随后为产生同样作用需增加药量,是较明确的药理依赖性指标。停
Benzodiazepines have been the first drug of choice for treating anxiety and insomnia in the years after their introduction in 1960, as well as anticonvulsants and muscle relaxants, replacing barbiturates. 1. Evidence of Drug Dependency It is well known that any drug, including placebo, can produce psychological dependence and that merely requiring continued medication is not sufficient to justify pharmacological dependence. However, if the drug is euphoric or can prevent discomfort and the patient voluntarily seeks for the drug, it indicates that the drug has a psychologically dependent psychological effect. Rapid tolerance, followed by the same role to increase the dose, is a more clear pharmacological dependence indicator. stop