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目的:评价黄芪注射液对病毒性心肌炎患者氧化应激和炎性反应影响。方法:选取2011年5月至2013年12月在本院心内科住院治疗的病毒性心肌炎患者178例,根据随机数字表分成联合组和常规组,常规组患者给予综合西医治疗,联合组在常规组治疗的基础上给予黄芪注射液静脉滴注。分别于患者入院后12 h和治疗2个疗程后对血清中超氧化物歧化酶(superoxide dismutase,SOD),丙二醛(malondialdehyde,MDA),谷胱甘肽转移酶(glutathione S-transferase,GST)和一氧化氮(nitric oxide,NO)浓度,以及白细胞介素-6(interleukin-6,IL-6),白细胞介素-8(interleukin-8,IL-8),肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和干扰素-γ(interferon-γ,IFN-γ)含量进行检测。结果:联合组总有效率为88.8%,远高于常规组的71.9%,差异具有统计学意义(P<0.05);治疗后,两组患者SOD和GST均较治疗前升高,MDA和NO均较治疗前降低,差异均具有统计学意义(P<0.05),联合组患者SOD和GST分别为(123.6±12.4)U·m L-1和(20.4±5.7)U·m L-1,均高于常规组;MDA和NO分别为(3.3±0.2)μmol·L-1和(68.4±10.9)mmol·L-1,均低于常规组,差异均具有统计学意义(P<0.05);治疗后,两组患者IL-6,IL-8,TNF-α和IFN-γ均较治疗前降低,差异均具有统计学意义(P<0.05),联合组患者治疗后IL-6,IL-8,TNF-α和IFN-γ分别为(43.5±20.3),(16.8±1.9),(8.9±1.5),(273.8±79.6)ng·L-1,均低于常规组,差异均具有统计学意义(P<0.05)。结论:黄芪注射液可以有效提高病毒性心肌炎临床治疗效果,减轻氧化应激和炎性反应对心肌细胞的损伤作用。
Objective: To evaluate the effect of astragalus injection on oxidative stress and inflammatory reaction in patients with viral myocarditis. Methods: From May 2011 to December 2013 in our hospital cardiology inpatient treatment of viral myocarditis 178 cases, according to the random number table divided into the joint group and the conventional group, the conventional group of patients given comprehensive Western medical treatment, the combined group in the conventional Group therapy based on the given intravenous infusion of Astragalus injection. The levels of serum superoxide dismutase (SOD), malondialdehyde (MDA), glutathione S-transferase (GST) were measured respectively after 12 h and two courses of treatment. And nitric oxide (NO) in serum and interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor- necrosis factor-α, TNF-α and interferon-γ (IFN-γ) were measured. Results: The total effective rate was 88.8% in the combined group, which was much higher than that in the conventional group (71.9%), the difference was statistically significant (P <0.05). After treatment, SOD and GST in both groups were higher than before treatment, MDA and NO (P <0.05). The SOD and GST in the combined group were (123.6 ± 12.4) U · m L-1 and (20.4 ± 5.7) U · m L-1, respectively, which were significantly lower than those before treatment (3.3 ± 0.2) μmol·L-1 and (68.4 ± 10.9) mmol·L-1, respectively, which were significantly lower than those in the control group (all P <0.05) After treatment, the levels of IL-6, IL-8, TNF-α and IFN-γ in both groups were significantly lower than those before treatment (all P <0.05) (43.5 ± 20.3), (16.8 ± 1.9), (8.9 ± 1.5) and (273.8 ± 79.6) ng · L-1, respectively, which were lower than those in the control group Statistical significance (P <0.05). Conclusion: Astragalus injection can effectively improve the clinical therapeutic effect of viral myocarditis and reduce the damage of oxidative stress and inflammatory reaction on myocardial cells.