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丝裂原活化蛋白激酶(MAPK)级联反应是细胞内的主要信息传递系统,能够将细胞外的刺激信号转导入细胞核,参与细胞生长、发育、分化和凋亡的过程。目前已发现3条MAPK信号转导通路,p38 MAPK通路是其中之一。p38蛋白分子具有4种亚型和6种异构体,不同亚型在各种组织细胞中有着不同的广泛表达。p38 MAPK通路能被MAPK激酶双重磷酸化和自体磷酸化两种方式调控,能激活多种蛋白酶,参与调节多种蛋白的生物作用。过度激活p38 MAPK通路能诱导胰岛β细胞凋亡,还能调节外周IS,影响IR,从而参与糖尿病的发生发展。本文就p38 MAPK通路的调节、激活,对糖尿病发生发展的研究进展进行文献复习和综述。
Mitogen-activated protein kinase (MAPK) cascade is a key information transmission system in cells. It can transduce extracellular stimuli into the nucleus and participate in the process of cell growth, development, differentiation and apoptosis. Currently, three MAPK signal transduction pathways have been found, one of which is the p38 MAPK pathway. The p38 protein has four subtypes and six isoforms, and different subtypes have widely different expression in various tissue cells. The p38 MAPK pathway can be double-phosphorylated MAPK kinase and autophosphorylation of two ways to regulate and activate a variety of proteases, involved in the regulation of a variety of biological role of the protein. Overexpression of p38 MAPK pathway can induce pancreatic β-cell apoptosis, but also regulate the peripheral IS, the impact of IR, which involved in the occurrence and development of diabetes. In this paper, the regulation and activation of p38 MAPK pathway, the development of diabetes mellitus were reviewed and reviewed.