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目的:分析我院由对比剂引发的药品不良反应(ADR)的特点,为降低造影检查的用药风险提供参考。方法:回顾我院近5年对比剂所引发的ADR,按对比剂品种,患者性别、年龄,ADR临床表现等进行统计分析。结果:调查期间我院共发生对比剂引发的ADR 52例,其中男16例,女36例,患者平均年龄为(56.8±13.0)岁,不良反应累及系统以皮肤及其附件的例数最多,对比剂的品种涉及非离子型碘对比剂碘佛醇、碘普罗胺、碘比醇及MRI对比剂钆喷酸葡胺,数量以碘普罗胺和碘佛醇为多。51例出现时间在注射后20 min内,1例出现在注射后60 min后。治愈5例,好转46例,死亡1例。结论:需重视对比剂引发的ADR,密切观察和积极干预可提高对比剂的用药安全性。
Objective: To analyze the characteristics of adverse drug reaction (ADR) caused by contrast agent in our hospital and provide reference for reducing the risk of medication for contrast-enhanced imaging. Methods: To review the ADR caused by contrast agent in the past five years in our hospital, and to make statistical analysis according to the contrast agent variety, patient’s sex, age, clinical manifestations of ADR and so on. Results: During the investigation, there were 52 cases of contrast-induced ADR in our hospital, including 16 males and 36 females, with a mean age of (56.8 ± 13.0) years. The number of adverse reactions involving the skin and its appendages was the highest, Contrast agent varieties related to non-ionic iodine contrast agent ioversol, iopromide, iodine alcohol and MRI contrast agent gadopentetate meglumine, the amount of iodoprolamine and ioversol as much. 51 cases occurred within 20 min after injection, 1 case occurred 60 min after injection. 5 cases were cured, 46 cases improved, 1 case died. Conclusion: It is necessary to pay attention to contrast-induced ADR. Close observation and positive intervention can improve the safety of contrast agent.