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二丙谷酰胺(曾用名:苯谷安)系胃泌素受体拮抗剂,具有抑制胃泌素分泌和保护胃粘膜作用的非抗胆碱药物。是一种治疗消化性溃疡的新型药物。 1979年以来中南制药厂在调研国外资料的基础上对二丙谷酰胺进行研制,完成了合成小试和中试放大试验,以及三废处理实验,拟定了临床样品的质量标准。浙江医科大学进行了动物急性、亚急性毒性试验。经北京、广东、广西、贵州、浙江,山东、上海、湖南等地的16所医院临床,对胃及十二指肠溃疡患者233例的近期疗效观察,采用每日口服1200～1600mg,疗程4～8周的方法,共愈合138例,好转58例,总有效率达84.1％。其中十二指肠溃疡患者149例,愈合92例,好转30例,有效率81.9％;胃溃疡84例,愈合46例,好转28例,有效率88.1％。临床观察证明二丙谷酰胺对临床症状的改善,溃疡的愈合有较明显的效果,且副作用很少,优于一般常用药物。1981年6月19～22日,由湖南省卫生厅、湖南省医药管理局主持的二丙谷酰胺鉴定会,在长沙市召开,参加会议的有36个单位的55位代表,与会代表对二丙谷酰胺的合成路线、质量标准、三废处理、临床药理等进行了认真的审议,一致认为二丙谷酰胺的合成路线选择合理,原料易得,操作简便,无特殊设备要求,三废处理可行,具备工业生产条件,建议报批投产。
Dipropylene glutamine (formerly known as: Gu Gu An) is a gastrin receptor antagonist, with inhibition of gastrin secretion and the role of non-anticholinergic mucosal drugs. Is a new drug for the treatment of peptic ulcer. Since 1979, Zhongnan Pharmaceutical Factory has developed dipropylene glutamine based on the research of foreign materials, completed the experiment of enlargement of small test and pilot scale, the experiment of waste treatment and the preparation of the quality standard of clinical samples. Zhejiang Medical University animal acute, subacute toxicity test. The clinical efficacy of 233 patients with gastric and duodenal ulcer in clinical observation of 16 hospitals in Beijing, Guangdong, Guangxi, Guizhou, Zhejiang, Shandong, Shanghai, Hunan and other places were observed. The daily oral doses of 1200 ~ 1600mg and treatment 4 ~ 8 weeks, a total of 138 cases of healing, improvement in 58 cases, the total effective rate of 84.1%. 149 cases of duodenal ulcer patients, 92 cases healed, 30 cases improved, the effective rate was 81.9%; 84 cases of gastric ulcer, 46 cases of healing, improvement in 28 cases, the effective rate was 88.1%. Clinical observations prove that dipyridamole for the improvement of clinical symptoms, ulcer healing has a more significant effect, and few side effects, better than the commonly used drugs. From June 19 to June 19, 1981, the Dipropylene Glutamine Identification Society hosted by Hunan Provincial Department of Health and Hunan Provincial Bureau of Medical Administration was held in Changsha City. There are 55 representatives of 36 units participating in the conference, The synthesis route, quality standard, waste treatment, clinical pharmacology and so on of propanamide have been conscientiously considered. It is agreed that the synthesis route of dipropylene glutamine is reasonable, the raw materials are easy to obtain, the operation is simple, no special equipment is required, With industrial production conditions, it is recommended approval for production.