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目的:探讨变应性因素在慢性鼻-鼻窦炎(CRS)发病过程中的作用。方法:分析194例CRS患者术前血清变应原检测(TIgE、SIgE)及变应原皮肤点刺试验(SPT)结果,并与临床分型进行比较。结果:①主要变应原分布:屋尘阳性率20.6%(40/194),粉尘螨阳性率16.0%(30/194),屋尘螨阳性率14.9%(29/194);②CRS实验组与正常对照组屋尘螨、粉尘螨、屋尘SIgE、SPT阳性率比较有统计学意义;③CRS实验组屋尘螨、粉尘螨、屋尘SIgE与临床分型呈负相关,差异有统计学意义。结论:部分变应性因素与CRS的病因及病程有关。
Objective: To investigate the role of allergic factors in the pathogenesis of chronic rhinosinusitis (CRS). Methods: Preoperative serum allergen test (TIgE, SIgE) and allergen skin prick test (SPT) were performed in 194 CRS patients and compared with clinical classification. Results: ①The distribution of major allergens was 20.6% (40/194), dust mite positive rate was 16.0% (30/194) and house dust mite positive rate was 14.9% (29/194) The positive rates of House dust mite, dust mite, house dust SIgE and SPT in the normal control group were statistically significant. ③ The house dust mites, dust mites and house dust SIgE were negatively correlated with the clinical classification in the CRS experimental group, the difference was statistically significant. Conclusion: Some allergic factors are related to the etiology and course of CRS.