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目的观察短疗程大剂量加速超分割放疗对晚期恶性肿瘤的近期疗效。方法晚期恶性肿瘤２０例，采用每次剂量３７０ｃＧｙ，每日２次，每次间隔≥６ｈｒ，连续照射２天为一疗程，每３周后可重复１个疗程，肿瘤灶剂量１４８０～４４４０ｃＧｙ／４～１２次／３～９周。结果肿瘤灶有效率为４５．８％，生活质量改善率７０％，主观症状改善率８０％。全组生存期１～２２个月，平均生存期５．２个月，３例存活期超过１年，其中２例分别超过１６个月和２２个月。放疗副反应较轻。结论短疗程大剂量加速超分割分段放疗对晚期恶性肿瘤具有较好的姑息治疗效果。
Objective To observe the short-term high-dose accelerated hyperfraction radiotherapy for the treatment of advanced malignant tumors in the near future. Methods Twenty patients with advanced malignant tumor were treated with 370cGy per dose twice a day for 6 hours at a time interval of 2 days. One course of treatment was repeated every 3 weeks. The dose of tumor was 1480-4440 cGy / 4 ~ 12 times / 3 ~ 9 weeks. Results The effective rate of tumor focus was 45.8%, the quality of life improvement rate was 70%, and the subjective symptom improvement rate was 80%. The overall survival of 1 to 22 months, the average survival of 5.2 months, 3 cases of survival of more than 1 year, of which 2 cases were more than 16 months and 22 months. Radiotherapy less side effects. Conclusions Short-course, high-dose, accelerated, fractional radiotherapy has a good palliative effect on advanced malignancies.