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目的观察美沙拉嗪治疗溃疡性结肠炎的临床效果。方法将河南省驻马店市新蔡县人民医院90例溃疡性结肠炎患者按照随机对照的方法均分成观察组和对照组(n=45)。对照组给予柳氮磺吡啶治疗,观察组给予美沙拉嗪治疗。比较2组患者最终治疗效果及不良反应情况。结果观察组45例患者,显效33例,有效10例,无效2例,总有效率97.8%;对照组45例患者,显效22例,有效11例,无效12例,总有效率73.3%。观察组治疗效果明显好于对照组(P<0.05)。观察组及对照组不良反应发生率分别为6.7%和31.1%,差异具有统计学意义(P<0.05)。结论美沙拉嗪治疗溃疡性结肠炎效果好于柳氮磺吡啶,疗效确切,且不良反应发生率低,值得在临床中推广应用
Objective To observe the clinical effect of mesalazine in the treatment of ulcerative colitis. Methods Ninety patients with ulcerative colitis in XinCai County People ’s Hospital of Zhumadian City, Henan Province were randomly divided into observation group and control group (n = 45). The control group was treated with sulfasalazine and the observation group with mesalazine. The final treatment and adverse reactions of the two groups were compared. Results In the observation group of 45 patients, 33 cases were markedly effective, 10 cases were effective and 2 cases were ineffective. The total effective rate was 97.8%. In the control group, 45 cases were markedly effective, 22 cases were effective, 11 were effective and 12 were ineffective. The total effective rate was 73.3%. Observation group, the treatment effect was significantly better than the control group (P <0.05). The incidence of adverse reactions in the observation group and the control group were 6.7% and 31.1%, respectively, with statistical significance (P <0.05). Conclusion Mesalazine is more effective than sulfasalazine in the treatment of ulcerative colitis, with definite curative effect and low incidence of adverse reactions, which is worthy of promotion and application in clinical practice