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目的了解福建省西南地区的泉州市、漳州市、龙岩市3个县(区)的结核分枝杆菌对一线抗结核药物的耐药情况,为今后结核病防治工作提供参考依据。方法采用WHO推荐的比例法对451株临床分离结核分枝杆菌进行药物敏感性试验。结果对异烟肼、利福平、链霉素、乙胺丁醇四种药物的总耐药率为20.4%,其中初始耐药率为19.0%,获得性耐药率为38.7%,耐多药(MDR)率为6.7%。结论福建省西南地区结核分枝杆菌耐药率较高,应引起相关卫生部门的关注。
Objective To understand the resistance of Mycobacterium tuberculosis to first-line anti-TB drugs in three counties (districts) of Quanzhou, Zhangzhou and Longyan in southwestern Fujian Province, and to provide reference for future prevention and treatment of tuberculosis. Methods 451 clinical isolates of Mycobacterium tuberculosis were tested for drug susceptibility by the proportion method recommended by WHO. Results The total resistance rates to isoniazid, rifampicin, streptomycin and ethambutol were 20.4%. The initial drug resistance rate was 19.0% and the acquired drug resistance rate was 38.7% Drug (MDR) rate of 6.7%. Conclusion The high rate of drug-resistant Mycobacterium tuberculosis in southwestern Fujian Province should arouse the concern of relevant health department.