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目的探讨人类白细胞抗原DR9(HLA-DR9)等位基因与新疆哈萨克族食管癌的相关性。方法采用1:2成组匹配病例对照研究,共收集哈萨克族食癌新发病例170例,对照340人,进行问卷调查,并采静脉血3mL检测HLA-DR9等位基因频率;采用Logistic回归模型及交互作用进行统计分析。结果病例组和对照组HLA-DR9等位基因频率分别为22.9%,9.1%,差异有统计学意义(χ2=18.29,P=0.000,OR=2.97);病例组和对照组有食管或胃病变史分别占26.5%,12.9%,差异有统计学意义(χ2=14.40,P=0.000,OR=2.42);病例组和对照组有食管癌家族史者分别占18.20%,8.80%,差异有统计学意义(χ2=9.53,P=0.002,OR=2.31)。Logistic回归分析及交互作用显示,HLA-DR9等位基因、食管或胃病变史以及食管癌家族史是哈萨克族食管癌的危险因素,且后2者均与HLA-DR9等位基因存在交互作用。结论HLA-DR9等位基因为哈萨克族食管癌的易感基因,与食管或胃病变、食管癌家族史之间存在交互作用。
Objective To investigate the association between human leukocyte antigen DR9 (HLA-DR9) alleles and Kazakh esophageal cancer in Xinjiang. Methods A 1: 2 matched case-control study was conducted in this study. A total of 170 newly diagnosed cases of esophageal cancer in Kazakh were collected and 340 were controlled by questionnaires. The frequency of HLA-DR9 alleles was detected by 3mL venous blood samples. Logistic regression model And interaction for statistical analysis. Results The frequencies of HLA-DR9 alleles in case group and control group were 22.9% and 9.1% respectively, with significant difference (χ2 = 18.29, P = 0.000, OR = 2.97). The cases and controls had esophageal or gastric lesions (Χ2 = 14.40, P = 0.000, OR = 2.42). The family history of esophageal cancer in case group and control group accounted for 18.20% and 8.80%, respectively, the difference was statistically significant Significance (χ2 = 9.53, P = 0.002, OR = 2.31). Logistic regression analysis and interaction showed that the history of HLA-DR9 alleles, esophageal or gastric lesions and family history of esophageal cancer were risk factors for Kazakh esophageal cancer, and the latter two had interaction with HLA-DR9 alleles. Conclusion The HLA-DR9 allele is a susceptible gene of Kazakh esophageal cancer and interacts with esophageal or gastric lesions and family history of esophageal cancer.