半胱天冬酶是ICE/CED-3蛋白酶家族的总称,在细胞凋亡中起着关键的作用。迄今已鉴定的人类半胱天冬酶共有11种,其底物可分为4类。半胱天冬酶的激活机制已初见端倪,有非自然抑制剂和自然抑制剂。抑制半胱天冬酶活性作为神经变性疾病的治疗途径已开始探索。 Caspases are the general term for the ICE / CED-3 protease family and play a key role in apoptosis. So far, human caspases have been identified a total of 11 species, the substrate can be divided into four categories. Caspase activation mechanism has begun to appear, there are non-natural inhibitors and natural inhibitors. Inhibition of caspase activity as a treatment for neurodegenerative diseases has begun to be explored.