利尿剂加用胍乙啶或心得安治疗较顽固的高血压病,可使患者获得较满意的降压疗效。胍乙啶可使处于休息状态和运动时的患者血清中去甲肾上腺素的浓度降低,可减少周围血管阻力,但并不影响心排血量。心得安则降低心肌收缩力和心排血量,并可降低血压。增加周围血管阻力。患者对这两种药物均有较好的耐受性。 Diuretic plus guanethidine or propranolol treatment of more stubborn hypertension, patients can get more satisfactory antihypertensive effect. Guanethidine can reduce the concentration of norepinephrine in the sera of patients at rest and during exercise, reduce peripheral vascular resistance, but does not affect cardiac output. An Ann is to reduce myocardial contractility and cardiac output, and lower blood pressure. Increase peripheral vascular resistance. Patients are better tolerated of both drugs.