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【目的】探讨微生态制剂在小儿腹泻治疗的临床疗效。【方法】选取本院2013年10月至2015年10月收治的221例腹泻患儿，按治疗方案的不同分为观察组和对照组。对照组按常规的抗生素结合肠黏膜保护治疗，观察组在对照组的基础上给予微生态制剂治疗。观察所有患儿一周大便性状、次数及全身症状改善情况。随访患儿出院后大便性状和食欲，以及有无消化不良症状，记录患儿腹泻复发等情况。【结果】观察组患儿腹痛、呕吐等症状明显好转，治疗4 d 、7 d 大便次数明显少于对照组，观察组的稀水样便症状持续时间短于对照组，差异均具有统计学意义（均 P ＜0．05）；观察组的有效率为94％，对照组的有效率为74％，差异具有统计学意义（χ2＝7．178， P ＝0．028＜0．05）；观察组复发率低于对照组，半年内复发率显著低于对照组，差异具有统计学意义（P ＜0．05）；观察组食欲不良率低于对照组，差异具有统计学意义（P ＜0．05）。【结论】微生态疗法能改善腹泻患儿病情，对小儿消化道功能的恢复具有积极的作用。“,”Objective]To investigate the clinical effect of micro ecological agents in the treatment of infantile diarrhea .[Methods]Two hundred and twenty‐two cases of children with diarrhea treated in the hospital were selected from October 2013 to October 2015 ,and were divided into observation group and control group according to different treatment options . The control group was treated with conventional antibiotic combined with intestinal mucosa protection ,and the observa‐tion group was treated with micro ecological agents on the basis of the control group .The improvement of one‐week stool situation ,frequency and whole body symptoms of all children were observed .After discharge ,the stool characters ,appe‐tite and indigestion symptoms(if any) were followed up ,and diarrhea symptoms were recorded .[Results]In the observa‐tion group ,abdominal pain ,vomiting and other symptoms were significantly improved ;on the fourth and seventh day af‐ter treatment ,stool frequency of the observation group was significantly less than that of the control group .In the obser‐vation group ,the symptom duration of watery stool was shorter than that of the control group ,the difference was statis‐tically significant (mean P < 0 .05) ;the effective rate of the observation group was 94% ,and that of the control group was 74% ,the difference was statistically significant (χ2 = 7 .178 ,P = 0 .028 < 0 .05) ;The recurrence rate of the observa‐tion group was lower than that of the control group ,the recurrence rate in 0 .5 year was significantly lower than that of the control group ,the difference was statistically significant ( P < 0 .05) ;The appetite loss rate of the observation group was lower than that of the control group ,the difference was statistically significant ( P < 0 .05) .[Conclusion]Microecological therapy can improve the condition of children with diarrhea ,and has a positive effect on the recovery of gastrointestinal function in children .