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一般认为慢性胰腺炎患者的胰腺外分泌功能不全是不可逆的。作者以内窥镜逆行性胆胰造影(ERCP),粪脂测定、尿对氨基苯甲酸(p-aminobenzoic acid,PABA)排泄和血清免疫反应性胰蛋白酶(immunore-active trypsin,IRT)测定,对70例患者进行前瞻性研究,经1～4年随访,发现它是可以逆转的。患者男62例、女8例,年龄27～69岁,从发生症状到确诊时间为3个月～10年,平均2.5年。诊断根据下述1个或多个指标:有至少2次腹痛发作伴血清淀粉酶升高的病史;腹部 X 线照片见胰腺钙化;无其它病因的
It is generally believed that pancreatic exocrine insufficiency in patients with chronic pancreatitis is irreversible. The authors used endoscopic retrograde cholangiopancreatography (ERCP), determination of fecal fat, excretion of p-aminobenzoic acid (PABA), and immunore-active trypsin (IRT) A prospective study of patients, after 1 to 4 years of follow-up, found that it can be reversed. There were 62 males and 8 females, ranging in age from 27 to 69 years old, with an average of 2.5 years from the onset of symptoms to a definite diagnosis of 3 months to 10 years. The diagnosis was based on one or more of the following indicators: a history of at least 2 episodes of abdominal pain with elevated serum amylase; abdominal calcification with pancreatic calcification; absence of other causes