应用不同剂量的新型氨基甾体处理小鼠急性粒 单核细胞性白血病动物模型 ,测定外周血白细胞计数及分类、骨髓未分化细胞百分率及脾重的变化。结果表明 :新型氨基甾体能明显降低小鼠粒单白血病动物模型的上述指标 (P <0 .0 1) ,且随着药物剂量的加大 ,后者明显降低 (P <0 .0 1)。提示新型氨基甾体对小鼠粒单白血病动物模型具有治疗作用 ,加大剂量可提高治疗效果。 Different doses of new aminosteroids were used to treat acute myelomonocytic leukemia in mice. The peripheral blood leukocyte count and classification, percentage of undifferentiated bone marrow cells, and spleen weight were determined. The results showed that the new aminosteroids can significantly reduce the above-mentioned index in the animal model of granulomonoclonal leukemia (P < 0.01), and with the increase of the drug dose, the latter significantly decreased (P <0. 01). It is suggested that the novel aminosteroids have a therapeutic effect on the mouse model of single leukemia, and increasing the dose can improve the therapeutic effect.