6-硫代脲酸,为用于治疗白血病的6-巯基嘌呤的主要代謝产物,因之它是一个具有生物价值的物质。鉴于在以脲酸和五硫化二磷合成本品的反应中,由于第八位上作用生成的付产物,須用阴离子交换剂始可分离除去,且操作較为繁杂,故作者采用了在合成嘌呤环以前用五硫化二磷选择性地在第四位上进行硫代反应的方法,制备了該类化合物。 6-Thiourea acid, the main metabolite of 6-mercaptopurine for the treatment of leukemia, is therefore a biologically valuable substance. In the reaction of urea and phosphorus pentasulfide synthesis of this product, due to the eighth place on the role of by-products generated by the anion exchanger to be separated before removal, and the operation is more complicated, so the author used before the synthesis of purine ring Compounds of this type are prepared by the selective reaction of phosphorus pentasulfide with the thio in the fourth position.