0 引言 新药发现的关键目标之一是新药的新作用特点。我国目前新药研究中，多数以仿制或跟踪性创新为主，且多集中在疾病机理相对清楚，既有药物种类较多的疾病；而对于许多难治性疾病，由于病理机制不明且缺少基本药物，可供仿制或修饰而获得新药信息十分有限，其新药研究则甚 0 Introduction One of the key targets for the discovery of new drugs is the new role of new drugs. Most of the current new drug research in China is based on imitation or follow-up innovation, and most of them focus on the disease mechanism is relatively clear. There are many kinds of diseases, and for many intractable diseases, the pathological mechanism is unknown and there is no essential drug. The information available for imitation or modification to obtain new drugs is very limited.