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目的探讨应用异丙酚和芬太尼作镇静麻醉辅助结肠镜检查的可行性,评价其效果和安全性。方法将10312例结肠镜检查患者分为两组。麻醉组(10112例):静脉注射异丙酚和芬太尼至患者进入4级镇静状态后进行结肠镜检查;对照组(200例):按常规进行结肠镜检查。观察两组检查前、检查开始后5m in和检查结束后的平均动脉压、心率、血氧饱和度以及检查反应和入镜时间。结果两组在检查过程中的平均动脉压变化差异有统计学意义(P<0.05),麻醉组在检查过程中心率和血氧饱和度的变化差异有统计学意义(P<0.05),但仍在正常范围内,而对照组心率和血氧饱和度的变化差异无统计学意义(P>0.05)。麻醉组的检查反应和入镜时间明显优于对照组(P<0.05)。结论异丙酚联合芬太尼辅助结肠镜检查是安全有效的,其检查反应和入镜时间优于普通结肠镜检查。
Objective To investigate the feasibility of sedation anesthesia with propofol and fentanyl assisted colonoscopy and evaluate its efficacy and safety. Methods 10312 colonoscopy patients were divided into two groups. The anesthesia group (10112 cases): intravenous injection of propofol and fentanyl until the patient entered the level 4 sedation after colonoscopy; control group (200 cases): routine colonoscopy. The mean arterial pressure, heart rate, blood oxygen saturation, and examination response and imaging time after the start of the examination and before the examination were observed before the two groups were examined. Results There were significant differences in mean arterial pressure changes between the two groups during the examination (P <0.05). There was also a significant difference in heart rate and oxygen saturation between the two groups during the examination (P <0.05) Within the normal range, there was no significant difference between the control group in heart rate and oxygen saturation (P> 0.05). The anesthesia group examination reaction and entry time was significantly better than the control group (P <0.05). Conclusion Propofol combined with fentanyl-assisted colonoscopy is safe and effective, and its response time and imaging time are superior to those of ordinary colonoscopy.