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本文以细菌内毒素为材料,模拟临床急性感染性疾病的“热症”模型,观察黄连(Coptis chincnsis Fwnch)对细菌内毒素解毒作用,以探讨其“清热解毒”的药理基础。实验结果表明:一、对内毒素所致大鼠死亡有保护作用,当大鼠腹腔注射内毒素,36小时内可使动物死亡45.5％,在注射内毒素后立即口服黄连煎剂,则可保护动物无一支死亡。二、对内毒素中毒大鼠血象观察,动物在内毒索攻击后2小时白细胞总数下降,24小时白细胞总数骤增,48小时又开始下降。黄连组与对照组相比,24小时内有促进白细胞升高的趋势,而48小时又比对照组下降更显著接近正常。黄连对白细胞分类无明显影响。三、对内毒素中素动物糖代谢的影响:由于内毒素引起组织细胞酵解能力增强及加速肝糖元分解,导致
In this paper, bacterial endotoxin was used as a model to simulate the “fever” model of acute infectious diseases in clinics. The effects of Coptis chincnsis Fwnch on the detoxification of bacterial endotoxin were observed to explore the pharmacological basis of “detoxification”. The experimental results showed that: 1, the endotoxin-induced death in rats have a protective effect, when rats were injected with endotoxin intraperitoneally, animals died within 45 hours 45.5%, after injection of endotoxin oral administration of Coptis decoction, you can protect No animal died. Second, endotoxin poisoning rat blood observation, animals in the endotoxin attack 2 hours after the total number of white blood cells decreased, the total number of leukocytes increased sharply 24 hours, 48 hours began to decline. Coptis group compared with the control group, within 24 hours to promote the trend of leukocytosis, and 48 hours more significantly lower than the control group close to normal. Coptis had no significant effect on leukocyte classification. Third, the impact of endotoxin in animal glycogen metabolism: due to endotoxin caused by increased ability of tissue cells to digest and accelerate glycogen decomposition, resulting in