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为进一步探讨干燥综合征(Sjogren Syndrome,SS)涎腺损害的机理,通过对18例SS患者组和6例对照组的研究,从形态上观察到:SS组淋巴细胞浸润在3级以上的病例(n=10),其部分导管上皮和腺泡细胞有典型的细胞凋亡征象,用DNA末端标记不仅确认为这10例中细胞凋亡的存在,而且发现了另外6例也有细胞凋亡,结果与对照组有显著性差异(P<0.01)。Fas抗原检测结果:18例患者均有不同程度表达,对照组未见阳性表达。表明涎腺组织细胞凋亡可能是SS口腔病损的主要形式之一,而且与Fas抗原表达及介导有关。淋巴细胞浸润严重组(n=10)与轻微组(n=8)之间Fas抗原表达有显著性差异(P<0.01)。表明Fas表达及介导的腺体组织的细胞凋亡与淋巴细胞浸润有关。
To further explore the mechanism of salivary gland damage in Sjogren Syndrome (SS), 18 cases of SS patients and 6 cases of control group were studied. The morphological changes were observed in patients with SS infiltration in grade 3 or higher (n = 10), some of the ductal epithelium and acinar cells typical signs of apoptosis, DNA end labeling not only confirmed the existence of these 10 cases of apoptosis, and found that there are 6 cases also have apoptosis, The results were significantly different from the control group (P <0.01). Fas antigen test results: 18 patients were different levels of expression, no positive expression in the control group. It is suggested that apoptosis of salivary gland tissue may be one of the major forms of oral mucosal lesions in SS and related to the expression and mediation of Fas antigen. There was significant difference (P <0.01) in the expression of Fas antigen among severe lymphocyte infiltration group (n = 10) and mild group (n = 8). It is indicated that Fas expression and apoptosis of glandular tissue are related to lymphocyte infiltration.