Melkersson-Rosenthal综合征(MRS)是一种罕见的未知病原的临床综合征。典型表现是复发性口面部肿胀、面神经麻痹及沟纹舌。大多数病例系家族性发病,一般认为是常染色体显性遗传伴不同表达方式。作者报告1例应用大剂量甲基强的松龙治疗的MRS患者。 Melkersson-Rosenthal syndrome (MRS) is a rare clinical syndrome of unknown pathogens. Typical performance is recurrent oral facial swelling, facial paralysis and grooved tongue. Most cases of familial onset, generally considered to be autosomal dominant with different forms of expression. The authors report a case of MRS patients treated with high-dose methylprednisolone.