自抗生素问世以来,特别是近数十年来,由广谱抗生素的应用而引起的合并症日渐增多。伪膜性肠炎便是值得注意的一种。尽管本病可以采用现代支持疗法,但其死亡率还是很高的。作者采用正常人粪便保留灌肠的方法(以下称粪便灌肠),取得了满意的疗效,现就8例临床治疗的情况报告如下。临床资料本组8例全系男性,年龄21～41岁。原发病有门脉高压症1例,溃疡病6例,左下肢血栓闭塞性脉管炎并肢体湿性坏疽1例。依次分别经过脾切除脾肾静脉分流术,胃大部切除术,胃窦部切除胃空肠吻合加迷走神经切断术,后者未行手术。全组病人在发生本病前均用了两种以上的抗生素,其中青霉素、链霉素合用者5例,青霉素、庆大霉素合用者3例,用药时间最短者4天,最长者8天。本病症状发生后,原使用的抗生素全部停用,而6例改用红霉素,2例改用新霉 Since the advent of antibiotics, especially in recent decades, the complication caused by the broad-spectrum antibiotics has been increasing. Pseudomembranous colitis is a noteworthy one. Although this disease can be treated with modern supportive care, its mortality is still high. The authors adopted the method of retention of enemas in normal human feces (hereinafter referred to as stool enema), and achieved satisfactory results, the report of 8 cases of clinical treatment is as follows. Clinical data of this group of 8 cases of all men, aged 21 to 41 years old. Primary disease with portal hypertension in 1 case, 6 cases of ulcer disease, left lower extremity thromboangiitis obliterans and limb wet gangrene in 1 case. Followed by splenectomy spleen and kidney vein shunt, subtotal gastrectomy, gastric anastomosis plus vagotomy and vagotomy, the latter without surgery. All patients before the onset of the disease were used more than two kinds of antibiotics, penicillin, streptomycin combined in 5 cases, penicillin, gentamicin combined in 3 cases, the shortest medication for 4 days, the longest 8 day. The symptoms of the disease, the original use of antibiotics all disabled, and 6 cases to erythromycin, 2 cases to Neoformans