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用激光多谱勒血流仪连续测量脑血流量（ＣＢＦ），观察３，４，５－三甲氧基苯甲酸－８－（二乙胺基）－辛酯（ＴＭＢ－８）对麻醉大鼠ＣＢＦ及脑血流自动调节功能的影响．结果表明，ＴＭＢ－８０．５，１．０和２．０ｍｇ·ｋｇ－１呈剂量依赖性地增加ＣＢＦ５％，２０％和３４％．其中仅２．０ｍｇ·ｋｇ－１组使平均动脉压（ＭＡＢＰ）降低６％．而尼莫地平（Ｎｉｍ）０．０１ｍｇ·ｋｇ－１在使ＣＢＦ增加２１％的同时，使ＭＡＢＰ降低了２７％．麻醉大鼠脑血流自动调节的ＭＡＢＰ低限是５．３ｋＰａ．在ＭＡＢＰ４．０ｋＰａ时ＴＭＢ－８２．０ｍｇ·ｋｇ－１能增加脑血流自动调节能力，而Ｎｉｍ０．０１ｍｇ·ｋｇ－１则无明显作用．提示ＴＭＢ－８增加ＣＢＦ和增强脑血流自动调节能力是其抗脑缺血作用的机理之一．
Cerebral blood flow (CBF) was measured continuously by laser Doppler flow cytometry. The effects of 3,4,5-trimethoxybenzoate-8- (diethylamino) -octyl ester (TMB-8) CBF and cerebral blood flow auto-regulating function. The results showed that TMB-80.5,1.0 and 2.0 mg · kg-1 increased CBF5%, 20% and 34% in a dose-dependent manner. Only 2.0mg · kg-1 group, mean arterial pressure (MABP) decreased by 6%. While Nim 0.01 mg · kg-1 reduced MABP by 27% while increasing CBF by 21%. The lower limit of MABP for the automatic regulation of cerebral blood flow in anesthetized rats was 5.3 kPa. At MABP 4.0 kPa, TMB-82.0 mg · kg-1 increased cerebral blood flow auto-regulation ability, while Nim0.01 mg · kg-1 had no obvious effect. Tip TMB-8 increase CBF and enhance the ability of cerebral blood flow regulation is one of its anti-cerebral ischemia mechanism.