在阿片受体激动剂和拮抗剂的研究中,普遍认为用环丙甲基取代阿片类镇痛药物氮上的甲基,可获得双重作用或拮抗性镇痛药。至今已用于受体研究和临床的非成瘾性或成瘾性较低的药物中,如纳屈酮(Naltrexone)、叔丁啡(Buprenorphine)和Diprenorphine等,在氮上均有环丙甲基。而溴代环丙甲烷则为引入环丙甲基的有效烃化剂。溴代环丙甲烷的合成方法之一是用四氢 In studies of opioid receptor agonists and antagonists, it is generally accepted that substitution of the methyl group on the nitrogen of the opioid analgesic with cyclopropylmethyl results in a dual or antagonist analgesic. So far, it has been used in receptor research and in clinical non-addictive or addictive drugs such as Naltrexone, Buprenorphine and Diprenorphine, base. Bromocyclopropylmethane is an effective alkylating agent for the introduction of cyclopropylmethyl. One of the methods for the synthesis of bromocyclopropane is the use of tetrahydro