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尿毒症患者心血管系统钙化发生早且严重,心瓣膜钙化较常见。心脏瓣膜钙化不仅能造成瓣膜狭窄和(或)关闭不全,同时还可引起心脏传导受损,导致心律失常、心室肥厚、心功能不全,甚至猝死等。研究表明多种因素参与了尿毒症的心瓣膜钙化,如钙磷代谢不平衡、甲状旁腺激素、活性维生素D、炎症、胎球蛋白A等。心瓣膜钙化是钙化促进因素与抑制因素不平衡的结果。本文就近年来国内外研究现状作一综述。
Uremic patients with early and severe cardiovascular calcification, heart valve calcification is more common. Cardiac valve calcification can not only cause valve stenosis and / or insufficiency, but also can cause impaired cardiac conduction, leading to arrhythmia, ventricular hypertrophy, cardiac insufficiency, and even sudden death. Studies have shown that many factors involved in the heart valve calcification of uremia, such as calcium and phosphorus metabolism imbalance, parathyroid hormone, active vitamin D, inflammation, fetuin A and so on. Cardiac valve calcification is a result of an imbalance between calcification and inhibition factors. This article summarizes the research status at home and abroad in recent years.