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目的 :初步观察碱性成纤维细胞生长因子 (b FGF)对庆大霉素 (Gentamicin,GM)肾毒性的治疗作用。方法 :雄性Wistar大鼠 32只 ,随机分为对照组、实验组 (GM)中的 GM1组、GM2组、GM3组各 8只。GM组按 16 0 m g/ kg· d- 1肌注GM 8d,对照组注射等量生理盐水。于实验第 9天宰杀对照组和 GM1组的各 8只动物 ,分别取血做血清尿素氮 (BU N)和血清肌酐 (Scr)检查 ,并取肾皮质做光镜检查。剩下的 GM2组、GM3组动物于实验第 9天停止肌注 GM,GM2组按 2 0 0 0单位 / kg· d- 1肌注 b FGF8d,而 GM3组注射等量生理盐水 ,之后又于第 9天再次给予 GM2组、 GM3组动物腹腔注射大剂量 GM,剂量为 40 0 mg/ kg· d- 1 ,分两次注射 ,共 4d,观察动物对大剂量 GM的耐受以及动物的存活情况。结果 :1血清学和形态学均显示 ,实验组动物有急性肾功能衰竭的表现 ;2经 b FGF治疗的实验组动物对大剂量 GM的耐受力明显增强。结论 :b FGF对 GM肾毒性有一定的治疗作用。
Objective: To observe the therapeutic effect of basic fibroblast growth factor (b FGF) on the nephrotoxicity of gentamicin (GM). Methods: Thirty-two male Wistar rats were randomly divided into control group, GM1 group, GM2 group and GM3 group. The GM group was injected with GM for 16 0 m g / kg · d-1 for 8 days, and the control group was injected with the same amount of saline. On the 9th day of the experiment, 8 animals in the control group and the GM1 group were sacrificed, and blood was taken for BU N and Scr examination, and renal cortex was examined by light microscopy. The remaining GM2 and GM3 animals stopped intramuscular injection of GM on the 9th day of the experiment, the GM2 group received intramuscular injection of bFGF8d at a dose of 200 units / kg · d-1, while the GM3 group received the same amount of normal saline, On the 9th day, the rats in the GM2 group were given GM2 again. The rats in the GM3 group were injected intraperitoneally with a large dose of GM at a dose of 40 0 mg / kg · d-1 for 4 days. The mice were observed for their tolerance to high doses of GM and their survival Happening. Results: 1 Serological and morphological studies showed that the animals in the experimental group had acute renal failure. 2 The experimental group treated with b FGF had significantly higher tolerance to high-dose GM. Conclusion: b FGF has a certain therapeutic effect on GM nephrotoxicity.