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目的探讨临床初复治肺结核的耐药情况。方法随机选取2012年5月~2013年3月在深圳市宝安区慢性病防治院进行治疗的耐药肺结核的患者160例,对这些患者的药物敏感试验的结果进行回顾性的分析,并与全国耐药情况调查进行对比分析。结果我国初复治的耐药情况与2010年的全国基线调查结果相比较,差异有统计学意义(P<0.05)。在单耐药中,对氧氟沙星耐药所占比例最大,占42.86%。结论本院的耐药比例明显高于全国的平均耐药水平,在治疗肺结核的过程中注意合理安排用药,尤其是合理应用喹诺酮类药物。
Objective To investigate the early drug-resistant pulmonary tuberculosis. Methods From May 2012 to March 2013, 160 patients with drug-resistant pulmonary tuberculosis who were treated in the Chronic Disease Prevention and Treatment Center of Bao’an District of Shenzhen City were randomly selected. The results of the drug-susceptibility test in these patients were retrospectively analyzed and compared with those of the national Drug situation survey conducted a comparative analysis. Results Compared with the national baseline survey in 2010, the difference of drug resistance in initial re-treatment in our country was statistically significant (P <0.05). In single drug resistance, the proportion of ofloxacin resistance is the largest, accounting for 42.86%. Conclusion The proportion of drug resistance in our hospital is obviously higher than the average level of drug resistance in our country. We should pay attention to the rational arrangement of medication in the treatment of pulmonary tuberculosis, especially the rational use of quinolones.