不明原因反复自发性流产(unexplained recurrent spontaneous abortion,URSA)由于其给患者造成较重的心理担忧而一直备受关注,但其病因十分错综复杂,至今尚未十分明了。临床上对这类患者的疗效亦不甚理想,因此,探讨和研究URSA的发病机制有其十分重要的临床意义。目前认为50%以上URSA与同种免疫有关,即与母胎界面滋养层细 Unexplained unexplained recurrent spontaneous abortion (URSA) has drawn much attention due to its heavy psychological concern to patients, but its etiology is complex and not yet clear. Clinical efficacy of these patients is not ideal, therefore, to explore and study the pathogenesis of URSA has its very important clinical significance. At present, more than 50% of URSA is considered to be related to alloimmunization, that is, the trophoblast interface with the maternal-fetal interface is fine