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目的探讨2型糖尿病肾病(DN)患者血清中超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)的水平变化及临床意义。方法选择临床确诊的住院和门诊的2型糖尿病患者(T2DM)131例,根据白蛋白排泄率(UAER)分为三组。单纯糖尿病组(DM组)44例,早期糖尿病肾病组45例(DN1组),糖尿病肾病组42例(DN2组),另选40例健康体检者作为对照组(CTL组)。采用酶联免疫吸附法测定标本血清中的hs-CRP、Hcy、TNF-α、IL-6和IL-8水平,并应用SPSS18.0进行数据分析。结果三组糖尿病组血清hs-CRP、Hcy、TNF-α、IL-6和IL-8浓度均高于健康体检组,差异有统计学意义(P<0.05),且DN2组高于DM组(P<0.05),UAER与hs-CRP、Hcy、TNF-α、IL-6和IL-8均成正相关(r均P<0.05)。结论 hs-CRP、Hcy、TNF-α、IL-6、IL-8及是2型DN病理生理过程中重要的炎症介质,在2型DN发生、发展过程中可能起重要作用;检测其水平有助于DN病情及预后判断。
Objective To investigate the changes of serum hs-CRP, Hcy, TNF-α, IL-6 in patients with type 2 diabetic nephropathy (DN) 6) and interleukin-8 (IL-8) levels and their clinical significance. Methods 131 cases of type 2 diabetes mellitus (T2DM) hospitalized and outpatient confirmed clinically were divided into three groups according to the albumin excretion rate (UAER). Forty-four patients in DM group (DM group), 45 in DN group (DN1 group), 42 in DN group (DN2 group) and 40 healthy individuals in control group (CTL group). Serum levels of hs-CRP, Hcy, TNF-α, IL-6 and IL-8 were measured by enzyme-linked immunosorbent assay and analyzed by SPSS18.0. Results The serum concentrations of hs-CRP, Hcy, TNF-α, IL-6 and IL-8 in the three diabetic groups were significantly higher than those in the healthy group (P <0.05) UAER was positively correlated with hs-CRP, Hcy, TNF-α, IL-6 and IL-8 (all P <0.05). Conclusions Hs-CRP, Hcy, TNF-α, IL-6, IL-8 and is an important inflammatory mediator in the pathophysiology of type 2 DN may play an important role in the occurrence and development of type 2 DN. Help DN disease and prognosis.