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已知铅可以阻碍血红素的合成及强烈地抑制氨基酮戊酸脱水酶(ALA-D)和亚铁络合酶。由此可引起血红素合成减少,血红蛋白降低。因此,常把ALA-D作为个体接触此环境化学物的最敏感指标。作者选择了年龄为17～55岁的107名男性汽车车体车间工人、专职汽车驾驶员和油库工人三种不同职业的人群为对象,分别获取有关其年龄、接触史和饮酒量等详细的资料。其研究目的在于用血铅水平与红细胞ALA-D和血卟啉总量的相关性作为铅接触的生物化学指标。
It is known that lead can block heme synthesis and strongly inhibit aminolevulinic acid dehydratase (ALA-D) and ferrous complex enzyme. This can lead to reduced hemoglobin synthesis, reduced hemoglobin. Therefore, ALA-D is often used as the most sensitive indicator of an individual’s exposure to this environmental chemical. The authors selected 107 male car body shop workers, full-time car drivers and oil depot workers from 17 to 55 years of age as subjects and obtained detailed information on their age, exposure history and alcohol consumption, respectively . The purpose of this study was to use the correlation between blood lead levels and total ALA-D and hematoporphyrin levels as a biochemical indicator of lead exposure.