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目的观察盐酸氨溴索预防肺癌患者胸部放疗后并发放射性肺炎的临床效果。方法 50例肺癌患者均采用直线加速器常规放射治疗,总剂量60～66Gy。治疗组25例患者静滴氨溴索60mg加0.9%氯化钠溶液100ml,每日两次,放疗第一天用至放疗结束;对照组单纯放疗。观察指标为NCICIC3.0分级,≥3级者,并对两实验组进行对比分析。结果 50例患者治疗后3个月急性放射性肺炎≥3级者治疗组为3例(12%);对照组为7例(28%);第6个月慢性肺纤维化治疗组发生率为7例(30.4%),对照组为12例(52.2%),两组比较差异有明显意义。结论氨溴索对急慢性放射性肺炎均有预防的效果。
Objective To observe the clinical efficacy of ambroxol hydrochloride in preventing radiation pneumonitis after chest radiotherapy in patients with lung cancer. Methods 50 cases of lung cancer patients were treated with conventional linear accelerator, the total dose of 60 ~ 66Gy. In the treatment group, 25 patients were given ambroxol 60mg plus 0.9% sodium chloride solution 100ml twice a day for the first day of radiotherapy until the end of radiotherapy. The control group received radiotherapy alone. The observation index was grade NCICIC3.0, grade≥3, and the two experimental groups were compared. Results Three cases (12%) were treated with acute radiation pneumonitis≥3 in 3 months after treatment, 7 cases (28%) in the control group, and the incidence of chronic pulmonary fibrosis in the 6th month was 7 Cases (30.4%), control group was 12 cases (52.2%), the difference between the two groups has obvious significance. Conclusion Ambroxol can prevent both acute and chronic radiation pneumonia.