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目的:分析p53过度表达与葡萄胎、恶性葡萄胎(恶葡)、绒毛膜癌(绒癌)的恶性程度及预后关系。方法:采用单克隆抗体免疫组化技术,对正常胎盘绒毛及妊娠滋养细胞肿瘤组织,进行肿瘤抑制基因p53表达检测。其中包括早期妊娠10例,中期妊娠10例,晚期妊娠13例,葡萄胎40例,恶葡9例,绒癌20例。结果:正常胎盘p53异常表达阴性,葡萄胎、恶葡、绒癌阳性表达率分别为42.5%(17/40)、55.5%(5/9)、85.0%(17/20)。正常胎盘与滋养细胞肿瘤之间以及葡萄胎、恶葡、绒癌之间,差异有显著性意义(P<0.01,P<0.05)。结论:p53的过度表达与滋养细胞肿瘤的恶性程度及预后有关
Objective: To analyze the relationship between the overexpression of p53 and the malignant degree of hydatidiform mole, malignant moles (neoplasms), choriocarcinomas (chorionic carcinoma), and prognosis. Methods: The expression of tumor suppressor gene p53 was detected in normal placental villi and gestational trophoblastic tumor tissues using monoclonal antibody immunohistochemistry. Including 10 cases of early pregnancy, 10 cases of mid-pregnancy, 13 cases of late pregnancy, 40 cases of hydatidiform mole, 9 cases of dysentery, 20 cases of choriocarcinoma. Results: Abnormal expression of p53 in normal placenta was negative. The positive rates of hydatidiform mole, malignant nevus, and choriocarcinoma were 42.5% (17/40), 55.5% (5/9), and 85.0% (17/20) respectively. ). There was a significant difference between normal placenta and trophoblastic tumors as well as moles, dystrophin and choriocarcinoma (P<0.01, P<0.05). Conclusion: Overexpression of p53 is associated with malignancy and prognosis of trophoblastic tumors