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目的：观察甲状旁腺激素（Ｐａｒｃｉｔｈｙｒｏｉｄ ｈｏｒｍｏｎｅ，ＰＴＨ） 对人牙乳头间充质细胞内外碱性磷酸酶活性的影响。方法：酶动力学方法。结果：在观察期间（３ ～７ｄ） ，ＰＴＨ 使人牙乳头间充质细胞内ＡＬＰ活性降低，而使细胞外ＡＬＰ活性增加，且有浓度依赖性。ＤＢｃＡＭＰ组可模拟ＰＴＨ 组的结果；ＰＴＨ＋ ＩＢＭＸ 组ＡＬＰ活性的变化大于单纯的ＰＴＨ 组，提示：ＰＴＨ 的作用通过细胞内ｃＡＭＰ介导。结论：ＰＴＨ 可能是成牙本质细胞分化的重要介质。
Objective: To observe the effect of Parcithyroid hormone (PTH) on alkaline phosphatase activity of human dental papilla mesenchymal cells. Methods: enzyme kinetic method. Results: During the observation period (3-7 d), PTH decreased the activity of ALP in human dental papilla mesenchymal cells and increased the activity of extracellular ALP in a concentration-dependent manner. DBcAMP group can simulate the results of PTH group; PTH + IBMX group ALP activity changes more than simple PTH group, suggesting that: the role of PTH mediated by intracellular cAMP. Conclusion: PTH may be an important mediator of odontoblast differentiation.