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肾移植后排斥反应病理组织学变化显示移植肾局部有免疫细胞渗出和血管及间质的病变。引起局部细胞增多的小分子物质,主要是细胞因子及其受体等,直接独立和/或与其相应的配体相互作用共同参与介导免疫排斥。在移植肾损伤的不同阶段,各类细胞因子参与免疫反应的功能与作用不尽相?
Rejection after renal transplantation histopathological changes showed that there are immune cells in transplant kidney cell exudation and vascular and interstitial lesions. Small molecules that cause local cell proliferation, mainly cytokines and their receptors, participate directly and / or with their corresponding ligand interactions to mediate immune rejection. Different stages of graft injury, various types of cytokines involved in the function and role of the immune response is not the same phase?