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目的 探讨慢性肾衰 (CRF)患者C反应蛋白 (CRP)水平对其促红细胞生成素 (EPO)的影响。方法 将CRF贫血患者根据CRP浓度分为CRP >10mg/L组和CRP <10mg/L组 ,用免疫学方法和生化检测技术测定 3 8例CRF贫血患者EPO ,血色素 (Hb) ,白蛋白 (Alb) ,血清铁 (Fe)等指标并进行统计学分析与处理。结果 将CRP >10mg/L组与CRP <10mg/L组进行比较 ,显示CRP >10mg/L肾性贫血患者的EPO水平相对较低并且CRP的浓度与血清Alb ,Fe水平呈负相关。结论 急性炎性蛋白CRP对EPO水平及其反应性有明显的干预作用 ,它可以作为CRF贫血患者EPO反应性的预测指标从一侧面判断不同CRF患者贫血纠正的难易程度 ,为发掘改善CRF贫血的正确途径提供参考
Objective To investigate the effect of C-reactive protein (CRP) on erythropoietin (EPO) in patients with chronic renal failure (CRF). Methods The patients with CRF anemia were divided into CRP> 10mg / L group and CRP <10mg / L group according to the concentration of CRP. EPO, hemoglobin (Hb), albumin (Alb) ), Serum iron (Fe) and other indicators and statistical analysis and processing. Results Compared with CRP <10mg / L group, CRP> 10mg / L group showed that EPO level in CRP> 10mg / L renal anemia patients was relatively low and CRP concentration was negatively correlated with serum Alb and Fe levels. Conclusions Acute inflammatory protein CRP has a significant effect on the level of EPO and its reactivity. It can be used as a predictor of EPO reactivity in patients with CRF anemia to determine the ease of correcting anemia in different CRF patients. The correct way to provide a reference